About 1921 several Romeo families requested Bishop Gallagher of Detroit, to  allow the celebration of Mass in Romeo.  Permission was granted, and Fr. Carroll came on Sunday each month from Rochester.

Since there was no church, Mass was offered in various homes and halls in the area.  A church was needed, but funds were lacking. The Extension Society loaned the parish $1,000 and Romeo became a mission of Lapeer under Fr. Thomas Carey, the pastor of Immaculate Conception Church, Lapeer.

A building committee purchased the first site, a lot on the corner of Rawles and W. Lafaytte Streets. Here the first church was built in 1924 under the direction of Fr. Thomas Gorman, who came from Lapeer to say Mass each Sunday.

St. Clement was established as a separate parish on July 5, 1939, with eighty-seven families.  Fr. Henry Koelzer was appointed as the first resident pastor. In 1949 the number of families had grown to 237.  A house and lot at 332 S. Main Street was purchased to be used as a parish rectory. The new school opened September 17, 1951, with church quarters in the school building opened for use on December 14, 1951. In 1965 twenty acres of land adjacent to the parish property was purchased. 

Plans were made to build a circular style church in 1966. With the floor plan chosen, it was decided to use as much as possible the work of local artists and artisans. The stone on the exterior of the church and also in the floor portion of the sanctuary is local field stone, hand-split and fitted by a local stone mason, Mr. Edward Mandeville. Large boulders found in the area were brought in by Mr. Leo Juip to be used as the Baptismal font, the holy water font, and the main altar. The new church was dedicated in 1968.

The organ was built by the Casavant Organ company of Quebec at the cost of $86,000.  It has twenty-three ranks and two manuals.  The acoustics in the church make for an outstanding sounding organ.

The bell tower and bells were dedicated in 1978.  The bells were cast in Holland of 80 percent copper and 20 percent virgin tin and are tuned to perfection based on the musical note A at 440 vibrations per second. They were installed by the I.T. Verdin Company.  The bells were donated by the Women's Guild, Men's Club and Mr. John Sweeney.

In the year 2000, it was decided to remodel the church and to build an addition which included the Religious Education Center, parish offices, chapel, overflow seating, gym and a social hall and gathering area. This addition was complete in 2001.